AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med., s1-26(2), 1946, pp. 189-208
Copyright © 1946 by American Journal of Tropical Medicine

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smithburn, K. C.
Right arrow Articles by Mahaffy, A. F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Smithburn, K. C.
Right arrow Articles by Mahaffy, A. F.

A Neurotropic Virus Isolated from Aedes Mosquitoes Caught in the Semliki Forest

K. C. Smithburn, A. J. Haddow AND A. F. Mahaffy1
From the Yellow Fever Research Institute, Entebbe, Uganda,2

1. A filterable virus, believed to be hitherto unknown, has been isolated from Aedes mosquitoes caught in uninhabited forest in western Uganda. It has been provisionally named Bunyamwera virus in respect of the locality in which it was encountered.
2. The agent is pathogenic for white mice and exerts its principal pathogenic effects on the nervous system regardless of the route by which it is introduced.
3. The effects of the virus in rhesus monkeys and rabbits are discussed.
4. The agent elicits the formation of virus-neutralizing antibodies in animals which survive inoculation. The presence of these antibodies may be ascertained by intracerebral or intraperitoneal tests.
5. Bunyamwera virus is immunologically different from the viruses of yellow fever, Bwamba fever, St. Louis and Japanese B encephalitis, Rift Valley fever, eastern and western equine encephalomyelitis and horse-sickness, from West Nile and Semliki Forest viruses and from another neurotropic virus isolated here but not yet reported.
6. Neutralizing antibody against the virus has been found in a forest monkey, in a human who suffered a recent attack of febrile illness characterized by marked neurological signs and in a number of persons sampled at random.


1 Staff Members of the International Health Division, Rockefeller Foundation.


2 This Institute is supported jointly by the Medical Department of the Uganda Protectorate and the International Health Division of The Rockefeller Foundation.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1946 by the American Society of Tropical Medicine and Hygiene.