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Chemotherapy of Human Filariasis by the Administration of Neostibosan¹

Thirty patients with filariasis (Wuchereria bancrofti) were treated with neostibosan for intervals ranging from 33 to 48 days. By the sixth month after treatment ended, microfilariae had disappeared from seven of the patients and had declined in all but one individual. In fifteen of the thirty treated patients, over 80 per cent of the microfilariae were lost during the six months of observation.

Among fifteen control untreated patients with filariasis, followed for the same period as those under treatment, thirteen persons showed an increase in microfilariae, one showed a small decline, and one presented no change in the number of circulating parasites.

Neostibosan has, therefore, appeared to exert a significant effect as a therapeutic agent in cases of filariasis bancrofti. It is impossible, however, as yet, to determine whether this effect is permanent, or subject to eventual relapse.

Received January 12, 1945.
¹ The authors wish to acknowledge the kindness of Dr. Pablo Morales Otero, Director of the School of Tropical Medicine, San Juan, Puerto Rico, in providing facilities for this study. They are grateful also to Dr. Ramón Suarez and to Dr. F. Hernandez Morales, of University Hospital, San Juan, for their interest in the work. Their best thanks are extended, likewise, to Dr. José Gándara, of the Insular Department of Health, who permitted treatment of certain patients in Hogar Insular de Niñas, Santurce, and Hogar Insular de Niños, Guaynabo, as well as to Dr. M. Pujadas Diaz, the Attending Physician of these institutions, who generously collaborated in the study. Finally acknowledgment is made of the helpful interest of Dr. James B. Rice, Director of Medical Research of the Winthrop Chemical Company, which supported the work.

² Read at the Fortieth Annual Meeting of the American Society of Tropical Medicine, at St. Louis, Mo. November 13–16, 1944.