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Heterophile Agglutinins and Cold Autohemagglutinins in Schistosomiasis, Filariasis, Malaria, and Leprosy

Heterophile agglutinin and cold autohemagglutinin titers were determined in 123 cases of schistosomiasis, 104 cases of filariasis, 40 untreated cases of malaria, and 18 cases of leprosy. In schistosomiasis, 4.9% had heterophile agglutinin titers over 1:32, in filariasis 13% had titers above 1:32, and of the malaria cases 5% had titers above 1:32; in no case was the titer higher than 1:128. In the small group of blood specimens from lepers, four showed a heterophile agglutinin titer of 1:128. Of twelve quinine-treated malaria cases, nine had a titer of 1:32 or lower, and three, a titer of 1:64.

Of the above group of 285 blood specimens, cold autohemagglutinins in a titer of 1:10 or higher could not be demonstrated in 279 or 97%. The few positive specimens showed no particular distribution and the highest titer noted was 1:80.

Received September 12, 1944.
¹ Major, M.C.

² Captain, M.C.