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Studies in Experimental Systemic Mycosis

I. Systemic Chromomycosis (Chromoblastomycosis) in Mice: Preliminary Study

The term chromoblastomycosis, as originally used by Terra and coworkers (1) to designate a fungus disease, was revised by Moore and de Almeida (2) to chromomycosis. The disease does not correspond to a true blastomycosis since the fungus divides, both in culture and in tissue, by cross wall or septum formation and not by budding. The newer term eliminates the possibility of confusion.

Numerous cases of chromomycosis have been reported throughout the world. The majority were caused by the fungus Hormodendrum pedrosoi, a few by the closely related Phialophora verrucosa.

The disease is rarely diagnosed clinically except in endemic areas, where its manifestations are generally considered to be largely limited to the skin of the lower extremities, especially of the feet and shanks. Lesions have, however, been described on the hand, ear, face, shoulder, arm, neck, buttocks, and thigh. It is the consensus that these are due to direct inoculation of the fungus into an area of local injury.

Received June 25, 1944.
¹ Mycologist, Department of Dermatology, Medical College of Virginia.