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Serological and Entomological Survey of Murine Typhus

The current problem of endemic typhus in the South and South-east necessitates more determined action towards the eradication of the reservoir rodent host, primarily from the infective foci. The conventional technique for detecting the disease in rodent populations involves the inoculation of rat brain or insect emulsions into guinea pigs and then the checking of the temperature reactions for the succeeding two or three weeks. If a thermal reaction is induced the problem is then resolved into identification by serum protection or immunization experiments. This entire process generally requires a minimum of three weeks, necessitating considerable assistance and materials.

During the past seven months the Eighth Service Command Laboratory has been interested in the typhus problem in and around San Antonio. Rats were originally examined by the guinea pig inoculation technique referred to above; however, it was found that the combined serological and entomological examination of the rats would give results of comparable significance.

Received October 4, 1944.
¹ Eighth Service Command Laboratory, Fort Sam Houston, Texas.