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The Adaptation of a Cane Rat (Zygodontomys) to the Laboratory and its Susceptibility to the Virus of Yellow Fever¹

The Villavicencio cane rat has been found to be well adapted to laboratory culture and manipulation.

The virus of yellow fever seems to grow readily in the brain tissue of this animal, but only about half of the animals are killed. Virus was successfully maintained for twelve serial passes and showed some signs of adaptation in that the rat mortality became successively higher and the incubation period shorter.

Circulating virus was not recovered after subcutaneous or intraperitoneal inoculation, but many animals showed circulating antibodies after such inoculation as well as after intracerebral inoculation as shown by the intracerebral protection test in white mice.

Received October 12, 1943.
¹ The studies and observations on which this paper is based were conducted with the support and under the auspices of the Section of Special Studies maintained by the Ministry of Labor, Hygiene, and Social Welfare of the Republic of Colombia and the International Health Division of The Rockefeller Foundation.