AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med., s1-23(6), 1943, pp. 597-606
Copyright © 1943 by American Journal of Tropical Medicine

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Immunization against Malaria

INCREASED PROTECTION BY VACCINATION OF DUCKLINGS WITH SALINE-INSOLUBLE RESIDUES OF PLASMODIUM LOPHURAE MIXED WITH A BACTERIAL TOXIN1

Henry R. Jacobs, M.D.
From the Department of Medicine, Northwestern University Medical School, Chicago

1. The water-insoluble plasmodial residues of P. lophurae appear to contain antigens which stimulate the formation of protective antibodies in the duckling.
2. The antigenicity of this material is increased by the addition of a bacterial toxin.
3. Certain features of the immunology of malaria are presented, and the hypothesis that the useful antigens are insoluble haptens is outlined.

Received March 5, 1943.
1 Eli Lilly and Company kindly furnished the protamine used in these and other experiments.






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Copyright © 1943 by the American Society of Tropical Medicine and Hygiene.