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Atabrine Retardation of Schizogony in Plasmodium Cathemerium Infected Canaries

Experiments are described in which I have attempted to utilize atabrine's ability to retard the rate of growth of asexual forms of P. cathemerium in the erythrocytes of infected canaries as a quantitative index of the drug's action. Even with the small dose employed the effect is regularly seen, but before the degree of this retardation is offered as a method by which the drug may be accurately compared with other antimalarial agents I feel it will be necessary to study a range of doses on both sides of the one which has been employed in the present study. Accordingly, the work will be extended and further findings duly reported.

Received January 15, 1940.