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Are the Experimental Data of Therapeutic Malaria Applicable to Conditions Obtaining in Nature?

As a general rule experience with induced malaria in paretics may be applied to ordinary malarial patients, provided one keeps the following points in mind:

a. If paretics are infected by mosquito bite, their reaction to drugs differs from that in ordinary patients only in that the bodily resistance, incited by a considerable number of fever attacks, promotes the action of the drugs; as a consequence somewhat smaller doses suffice and clinical relapses are fewer.

b. In treating paretics whose malaria had been induced by blood inoculation the possibility of relapses in benign tertian and quartan malaria may be ruled out altogether. Here again smaller doses than used in ordinary practice suffice.

Received May 30, 1941.