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Histoplasma Capsulatum: Its Cultivation on the Chorio-Allantoic Membrane of the Developing Chick and Resultant Lesions¹

1. The chorio-allantoic membrane of the developing chick was successfully inoculated with a seven year old culture of Histoplasma capsulatum.

2. Eggs were incubated 12 days and observed 6 days after inoculation.

3. The macroscopic appearance of the lesion showed a thickened, yellowish-gray plaque with a peripheral opaque region.

4. Microscopically, there was a marked reaction in the ectoderm, mesoderm, and the underlying entoderm.

5. The cellular response consisted of the appearance of large numbers of fibroblasts, monocytes, leucocytes, red blood cells with a marked eosinophilia.

6. The organism showed a conversion into yeastlike cells analogous to the formation of arthrospores and oidia.

7. The ascus-like cells, stalagmospores or aleuriospores became converted into many yeastlike cells which seemed to indicate that they are most likely ascus-like structures, probably of a degenerate nature.

Received January 10, 1941.
¹ Studies, observations and reports from the Departments of Dermatology and Mycology of the Barnard Free Skin and Cancer Hospital, service of Dr. M. F. Engman, Sr.