HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bugher, J. C. Search for Related Content PubMed Articles by Bugher, J. C.

The Use of Baby Mice in Yellow Fever Studies¹

1. Baby Swiss mice of less than nine days of age exhibit a high degree of susceptibility to both neurotropic and viscerotropic strains of yellow fever virus administered subcutaneously. The susceptibility is equivalent to that of adult mice of the same strain inoculated intracerebrally.

2. The incubation period with both neurotropic and viscerotropic viruses is prolonged in comparison with the same viruses inoculated intracerebrally in adult mice.

3. The marked difference in incubation times between the two strain types of virus, as seen in mice inoculated intracerebrally, is not encountered when the same viruses are studied by the subcutaneous route in baby mice.

4. The technic for the employment of baby mice in insect transmission experiments is described. An illustrative experiment with infected Aëdes aegypti mosquitoes is given.

5. With Aëdes aegypti mosquitoes infected with jungle virus, transmission to baby mice occurred with about the same frequency among those biting without engorgement as among those which filled with blood.

Received May 10, 1940.
¹ The studies and observations on which this paper is based were conducted with the support and under the auspices of the Section of Special Studies maintained by the Ministry of Labor, Hygiene and Social Welfare of the Republic of Colombia and the International Health Division of The Rockefeller Foundation.