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The "Short-Term" Treatment of Malarial Infections with Quinine¹

At the present time malariologists appear to be divided into two schools as regards the method of treating malarial infections with quinine. Those belonging to the first, or oldest school, believe in the prompt treatment of acute symptomatic infections with enough quinine to control the symptoms, after which the drug is continued in smaller doses for a period of time considered sufficient to eliminate the infection, usually for from six to eight weeks. Those belonging to the second school believe in treating the acute symptoms with sufficient quinine to control them, after which the drug is stopped and relapses are allowed to occur, the acute symptoms of each relapse being controlled with quinine, after which the drug is discontinued as before. The first method of treatment aims at eliminating the infection and, if conscientiously followed, results in such elimination in many cases without relapses occurring during the course of treatment.

Received November 23, 1939.
¹ Read at a Joint Session of The American Society of Tropical Medicine and the National Malaria Committee at Memphis, Tennessee, November 23, 1939.