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A Note on the Effect of Tartar Emetic Intravenously on the Non-Protein Nitrogen of the Blood

The more or less specific effect of tartar emetic intravenously in conditions known as granuloma inguinale has brought to the attention of the profession of this country a drug about which little is generally known. Reports of cases of granuloma inguinale coming from various parts of the United States indicate that this infection may be encountered in any latitude. The combination of the tartrate with antimony to form tartar emetic gives us a compound in which either of its components may cause serious effects when given in toxic doses or to susceptible individuals. Experimental work conducted by Underhill, Pearce and Ringer, Salant, and others, has shown that the tartrates when injected into dogs and rabbits are capable of producing a definite nephritis with retention of the non-protein nitrogen elements in the blood. While such work has not been done with antimony, the similarity of the drug with arsenic suggests that it would produce the same effect as arsenic in the individual.

Received May 23, 1922.