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Typhus Fever in Boston and a Review of the Newer Methods of Diagnosing Typhus¹

TABLE OF CONTENTS I. Introductory 225

II. Review of literature 228

1. The typhoid group and the Widal reaction in typhus 228

2. The proteus reaction of Wilson, Weil and Felix 231

1. Technic 232

2. Technical errors 233

3. Significance of titer 234

4. Nature of reaction 234

5. O and H forms 235

6. Interpretation of reaction 236

7. The reaction with preserved cultures 238

8. Summary 238

9. Conclusions 238

3. Pathology in man and guinea-pigs. The guinea-pig test 239

4. Less important aids to diagnosis 241

1. Blood picture 241

2. Cerebro-spinal fluid 242

3. Weil-Kafka reaction 243

4. Complement fixation 243

5. Clouding reaction of Weltmann 243

6. Anaphylactic reaction 244

7. Skin reactions of Friedberger and of Lipschüts 244

8. Deitsch's congestion test 244

9. Wiener's color reaction 245

5. Miscellaneous observations 245

III. Conclusions in brief 246

I. INTRODUCTORY

¹ Read in part at the Seventeenth Annual Meeting of the American Society of Tropical Medicine at Hot Springs, Arkansas, Noyember 14–15, 1921.