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The Effect of Emetinized Blood and Serum from Man and Cat on Pathogenic Entamoebae in Stools

It has been conclusively demonstrated (1) that emetine hydrochlorid is not particularly toxic when applied directly to pathogenic entamoebae within the time limit of one to two hours. Inasmuch as emetine will generally abolish entamoebic dysentery in man, but has no effect on the same infection when transferred to cats, Dale and Dobell (2) have pointed out that emetine acts upon the host rather than upon the parasite.

We have undertaken to investigate the possibility of reproducing this reaction outside of the body by, first, mixing emetine with blood and serum from man and cat, and second, by injecting man and cat with therapeutic doses of emetine, withdrawing blood after absorption, and then applying these various mixtures to pathogenic entamoebae in stools.

The entamoebae for the first set of observations were obtained from a young white man who developed bloody painful dysentery on the Western Front in 1918 and who has several times been partially treated within the past two years.

Received December 1, 1921.