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Atabrine Prophylaxis in Malaria

Report of Third Year's Investigation

1. The basis for chemoprophylaxis of malaria with atabrine is presented.

2. The results achieved by other investigators are briefly reviewed.

3. The factors which may influence the relative effectiveness of antimalarial drugs are outlined.

4. The results of experiments to control malaria by daily prophylactic doses of 50 mgm. of atabrine in the Harris Neck region of Georgia in 1937 are reported, with a brief summary of the similar experience during the previous two years.

5. The rôle of atabrine in the achievement of success is evaluated.

6. The reduction of malaria morbidity by prophylaxis with atabrine was not dependent on a fall of malarial intensity (or the ‘down’ curve of a malarial cycle) nor on meteorologic conditions.

7. The results have been so encouraging that a further trial is warranted; consequently, a fourth year's work has been undertaken and will be reported subsequently.

8. No untoward reactions or toxic symptoms due to atabrine were observed although many individuals received as much as 25 grams of atabrine over the three year period.

Received August 8, 1938.