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Susceptibility and Resistance of Various Species of Peromyscus (American Deer Mice) to Infection with Trypanosoma Hippicum, and the Possibility of Certain "Wild Mice" Being Reservoir Hosts to Pathogenic Trypanosomes¹

Several species and subspecies of American deer mice, genus Peromyscus, were inoculated with Trypanosoma hippicum.

1. In the following species and subspecies Trypanosoma hippicum infection ran an acute course: P. eremicus anthoni, P. e. eremicus, P. e. fraterculus, Mus bacterianus and Mus musculus. No crises of trypanosomes were demonstrable. All animals of the above species succumbed to the disease within two weeks.

2. In the following species and subspecies the infection ran a subacute course: P. maniculatus artemisiae, P. m. gambelii, P. m. rubidus, P. m. rufinus and P. m. sonorensis. Frequent crises and relapses of Trypanosoma hippicum were demonstrable in the peripheral blood of these animals. The minimum period of life was 34 days, the maximum over 250 days, and the general average 95 days. From the first sign of infection until their death, their blood was infective and fatal to Mus musculus and Rattus norvegicus, killing them within 15 days.

3. The possibility of wild mice being reservoir hosts for pathogenic trypanosomiases is suggested.

Received August 14, 1937.
¹ Read at Thirty-first Annual Meeting of the American Society of Tropical Medicine, St. Louis, Missouri, November 20, 1935.

I wish to express my appreciation and gratitude to Dr. C. Kofoid at the University of California for sending me the strains of Tr. hippicum; and to Dr. Lee R. Dice and Dr. H. Clark at the University of Michigan, and to Dr. R. R. Huestis at the University of Oregon for supplying several species of Peromyscus.

² A part of this study was performed in the Department of Bacteriology and Immunology, Medical School, Washington University, St. Louis, Missouri, during 1933–1934.