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Granuloma Inguinale¹

1. A series of 294 cases of granuloma inguinale observed in New Orleans during the years 1931 to 1935 is reported.

2. The analysis of the clinical symptoms suggests that the disease is a strictly local infection with no dissemination of the infectious agent and no general toxicity. Secondary infections have to be regarded as serious complications of the disease.

3. An attempt has been made to divide the lesions, according to their appearance, into five principal groups, the most common one being the serpiginous ulcer of the pudenda.

4. The genital organs must be regarded as the site of predilection for the disease, followed by the inguinal and perineal regions. The extragenital lesions are rare and usually secondary to pudendal lesions.

5. The histopathology of the five principal types of lesions is described. A brief stage of exudative inflammation is followed by a chronic productive inflammatory process leading to the formation of the serpiginous ulcer, the hypertrophic and cicatricial lesions.

6. Certain cicatricial lesions which have been interpreted as the scar tissue of healing ulcers represent an active and progressive manifestation of the disease.

Received November 19, 1936.
¹ Read at the annual meeting of the American Society of Tropical Medicine at Baltimore, Maryland, November 18, 19 and 20, 1936.