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In rabbits which resist an infection with the trypanosome, Trypanosoma brucei, there is a significant increase in the relative percentage and in the total number of monocytic cells of the blood just prior to the parasite crisis. Non-resistant rabbits and rats show no such increase in monocytic cells and promptly succumb to the infection in spite of the very marked increase in the relative and the absolute numbers of polymorphonuclear leucocytes. It seems possible that the greater resistance of most rabbits, compared with rats, to this parasite is reflected in their capacity to develop an enhanced number of monocytic cells, these cells being related possibly causally to the crisis in the parasite number which follows the appearance of them.
Received February 10, 1937.
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