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Studies on the Pathology of Amebic Enteritis in Dogs¹

1. The amebic process in the untreated dog is described in detail. Three stages of invasion have been recognized: (1) extensive superficial denudation of the mucosa, similar to that in the kitten, except that the solitary lymph nodes in the dog are protected by epithelium and do not usually partake of the injury; (2) typical deep bottle-neck ulceration,unaccompanied by cellular infiltration; and (3) chronic undermining ulceration,with superficial sloughing, frequently complicated by bacterial invasion.The second and third types most nearly correspond to the human amebic process.

2. The cecum is the earliest site which the amebae choose for attack, although in later, more chronic cases, the more evident and frequently the deeper lesions are situated in the lower colon and the rectum.

3. The earliest superficial tissue changes, as well as the typical bottle-neck ulcers and the honeycombing destruction of the submucosa, all indicate that lytic action is most important in the development of the amebic process, although mechanical action probably aids the amebae in their penetration and migration. While bacteria, accompanying or following the amebae, unmistakably complicate the picture, there is adequate evidence that the amebae alone are responsible for the typical lesion

4. Amebae in uncomplicated cases provoke no polymorphonuclear leukocyte infiltration, although monocytes may invade the damaged area. They do not stimulate the solitary lymph nodes appreciably. Where bacteria accompany or follow the amebae, there is profound leukocytic infiltration and lymph node response.

Aided by a grant form the David Trautman Schwartz Reseach Fund. Read before the Section on Medical Sciences, New Orleans Academy of Sciences, 81st Annual Meeting, March 23, 1934.