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Hydroquinidine in Malaria¹

In 16 smear-positive patients with malaria hydroquinidine sulphate in dose of 10 grains (0.65 grams) daily for four days about four hours before chill time, caused in every case disappearance of parasites from the blood and cessation of symptoms by the fifth day. There were 4 cases of estivo-autumnal infection, 12 of benign tertian.

In so far as concerns the immediate results of a short course of treatment, the conclusion of Giemsa and Werner (4) is confirmed, that hydroquinidine appears equal to quinine in antimalarial activity.

Hydroquinidine in single 10-grain (0.65 grams) dose of the sulphate daily was well tolerated, producing cinchonism (vertigo) in only 1 case. In 1 case this dose was given daily for forty-eight days, and a 5 grain dose daily for the following twenty-five days, without ill effect.

¹ This work has been aided by a grant from the Committee on Scientific Research of the American Medical Association.