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Amebiasis in Panama and California with Special Reference to Incidence and Treatment¹

A relatively high incidence of amebiasis (E. histolytica) presumably exists in Guatemala, Costa Rica, and the interior of Panama. In the Hospital Santo Tomas in Panama City, however, only 13.9 per cent of a selected group of patients (from the men's medical, women's medical, and obstetrical wards) were found to harbor E. histolytica. In recent California surveys where comparable laboratory methods were used (wet fixed iron hemotoxylin stained smears examined) there has been reported an incidence of 9.8 to 16 per cent. Eighty-eight of the 101 Panama cases of amebiasis found on 1834 examinations were treated with Carbarsone (carbamino-phenyl-arsonic acid containing 28.8 per cent arsenic) given orally in average dosage of 5.0 grams for ten days. This amebacide was effective without adjuvant in clearing all but one of 37 cases that could be followed during the month of therapy. No evidence of arsenic toxicity was noted when total doses to 300 mgm. per kilogram were given orally.

¹ Read before the American College of Physicians, Sixteenth Annual Clinical Session, San Francisco, California, April 6, 1932.

From the Gorgas Memorial Laboratory, Panama; the Pacific Institute of Tropical Medicine; and the Pharmacological Laboratory, University of California Medical School, San Francisco.

Supported in part by Eli Lilly and Company, Indianapolis, Indiana, and the Panama Mail Steamship Company, San Francisco. Through the kindness of Dr. Herbert C. Clark and Dr. William M. James we were given laboratory space and supplies int he Gorgas Memorial Laboratory to carry out this study.

With the technical assistance of (Mrs.) Dorothy Koch Donaldson.