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Malaria Prophylaxis with Chinoplasmin

A Field Experiment¹

R. L. Holt
United States Army Medical Department Research Board, Manilla, Philippine Islands

Daily doses of 0.01 gram of plasmochin and 0.3 gram of quinine sulphate in the form of tablets of chinoplasmin are not always sufficient to prevent the appearance of malaria parasites in the blood, although they occasionally do so and will usually forestall clinical symptoms. Such doses are well tolerated for periods up to fifty-seven days.

Even doses of 0.02 gram of plasmochin and 0.6 gram of quinine sulphate permit the occasional development of malaria parasites in the blood.

¹ This experiment was carried on jointly by the United States Army Medical Department Research Board and the Malaria Investigations Laboratory. The latter is coöperatively supported by the International Health Division of The Rockefeller Foundation and the Bureau of Science, Manilla.

Special mention should be made of the assistance of Private Bonifacio Reyes who administered the drug and who took the blood smears.

We are indebted to the Winthrop Chemical Company (Dr. G. Schwab, local manager) for supplying, without charge, the chinoplasmin used in this experiment.