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Studies in Black-Water Fever

PART I. VARIATION IN THE INTENSITY OF HAEMOGLOBINURIA FOLLOWING ADMINISTRATION OF QUININE BY REGULATION OF THE DOSAGE OF QUININE IN A SUSCEPTIBLE INDIVIDUAL¹

UPENDRANATH BRAHMACHARI AND PHANINDRANATH BRAHMACHARI

Whatever may be the mechanism of black-water fever, there is no doubt that there are many cases in which quinine is a determining factor and its administration may be followed by severe haemoglobinuria and sometimes with disastrous results, while in other cases, quinine has little or no influence upon the disease. The disease may therefore be classified under two heads:

1. Quinine-intolerant type. This includes cases in which haemoglobinuria is precipitated by the administration of quinine. It can be subdivided into two groups:

(a) Mild in which the haemoglobinuria stops as soon as quinine is discontinued.

(b) Severe in which haemoglobinuria persists after the discontinuance of quinine and the condition may end fatally.

¹ From the Brahmachari Research Institute, Calcutta. Physician, Medical College Hospital, Calcutta.