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Quinine Analysis of the Blood with Reference to the Treatment of Malaria

The literature on the treatment of malaria shows that the technique of quinine administration is subject to wide variations. It would be expected that these variations would markedly influence the results obtained in the treatment, but apparently almost any method of exhibiting this drug has been found "satisfactory." Perhaps the most important single factor accounting for this unexpected result is the tendency of the individual to clear his system of the parasites when given slight assistance. This factor is at present being given considerable emphasis by certain English authorities, notably by James (1). In referring to induced malaria, resulting from mosquito bites, James states that, "Even large doses (30 grains or more) given during the incubation period have no effect; a large dose (15 grains) given on the first day of the attack has little effect.