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Attempts to Produce Bronchomoniliasis in Monkeys

The intratracheal, intravenous and direct inoculation into the lung of Monilia tropicalis isolated from a fatal case of bronchomoniliasis failed to induce pulmonary infection in monkeys. Two normal animals were inoculated intratracheally in attempts to induce a primary infection, without success. In the other monkeys efforts were made to reduce the resistance of the lung by the injection of inert foreign bodies, by actual laceration of the lung and by the intravenous injection of chaulmoogra oil, hoping thereby to permit the growth of monilia as a secondary invader in damaged tissue.

Several suggestions to explain the failure to produce lesions may be mentioned, (a) monkeys may be resistant to monilia infection or the strain used may have been avirulent for these animals; (b) the lung may not have been damaged severely enough to permit the organisms to gain a foothold; (c) the monilia may not have reached the damaged tissue; (d) there was no obstruction in the bronchi to prevent the evacuation of the inoculum; (e) the monilia inoculated were from young cultures in the yeast-like stage of their life cycle. It has been suggested that in the mycelial or older stage the organisms are more resistant and invasive. In another communication (2) the formation of tubercle-like nodules in the traumatized lung of rabbits following the inoculation of old cultures of Monilia tropicalis is reported.