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A Biochemical Study of Two Patients with a Condition Simulating Sprue¹

This report presents biochemical data made during two years observation of two patients having fat diarrhea, so-called non-tropical sprue; they also show the subsidiary symptoms of this condition, namely, emaciation, anemia and tetany. Clinical description of these patients has appeared in the article by Holmes and Starr (1) on non-tropical sprue.

As far as we know, no complete metabolic studies have been made in sprue. The attention of most observers has been on bacteriology. Scott (2) has drawn attention to calcium in the diagnosis and treatment of sprue, but since he uses Vines' technic to determine serum calcium and gives 1/10 grain parathyroid extract twice a day by mouth and administers only 15 grains of calcium lactate three times a day, it would seem that his success, i.e. "the symptoms clear up with marvelous rapidity," is not to be attributed to any innovation in therapeutics.

¹ Read before the Central Society for Clinical Research, November 23, 1928.