AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med., s1-10(4), 1930, pp. 249-259
Copyright © 1930 by American Journal of Tropical Medicine

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Anderson, H. H.
Right arrow Articles by Leake, C. D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Anderson, H. H.
Right arrow Articles by Leake, C. D.

The Oral Toxicity of Emetine Hydrochloride and Certain Related Compounds in Rabbits and Cats1,2,

Hamilton H. Anderson2 AND Chauncey D. Leake
From the Pharmacological Laboratory of the University of California Medical School, San Francisco, and the Pacific Institute of Tropical Medicine, Hooper Foundation for Medical Research

The minimal lethal dose of emetine hydrochloride given orally in enteric coated capsules is 15 to 20 mgm./kgm. for rabbits and cats. Of emetine bismuth iodide it is 50 mgm./kgm. for rabbits and 30 to 40 mgm./kgm. for cats; of emetine antimony iodide it is 30 mgm./kgm. for rabbits and 15 to 20 mgm./kgm. for cats; of auremetine it is 100 to 125 mgm./kgm. for rabbits and 30 to 40 mgm./kgm. for cats, and of iso-amyl cephaeline phosphate it is 300 to 350 mgm./kgm. for rabbits and 200 to 250 mgm./kgm. for cats. Postmortem examination revealed degenerative injury to cardiac and smooth muscle and to liver and kidney following lethal doses of all these drugs.

Since the minimal lethal dose of emetine hydrochloride by mouth is in the same range as that given subcutaneously, fairly complete absorption from the gut is indicated. Again, since the minimal lethal dose on single subcutaneous injection or on single dose by mouth is in the same range as when given in small divided doses daily, an extremely slow rate of elimination or detoxification of the drug is indicated. The significance of the toxic range of such a drug as emetine is discussed.


1 This report is based on part of an extended coöperative study of the chemotherapy of amebiasis conducted by the Pharmacological Laboratory of the University of California Medical School and the Pacific Institute of Tropical Medicine, Hooper Foundation for Medical Research, San Francisco.


2 Lilly Research Fellow.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1930 by the American Society of Tropical Medicine and Hygiene.