HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gaudette, L. E. Articles by Coatney, G. R. Search for Related Content PubMed PubMed Citation Articles by Gaudette, L. E. Articles by Coatney, G. R.

Stability of Primaquine Diphosphate under Various Conditions

When primaquine diphosphate was subjected to conditions simulating those ordinarily occurring in the preparation of food, it was found to be unstable. Spectrophotometric analysis indicated a destruction of from 5% to 94% depending upon the conditions of heating. However, when the heated samples were tested against Plasmodium gallinaceum in young chicks, all activity was absent except in the sample boiled in water for 24 hours and in this instance the activity was of a very low order. These findings exclude the use of primaquine as a salt additive in malaria eradication programs.

^* Present address: Laboratory of Biochemical Pharmacology, Joseph E. Seagram and Sons, Inc., Scientific Department, Cranbury, New Jersey.