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The Use of Dithiazanine Iodide in the Treatment of Multiple Helminthiasis in Sarawak, Borneo

Thirty-five patients with multiple infections of Ascaris lumbricoides, Trichuris trichiura, and Ancylostoma duodenale were treated with dithiazanine iodide at a dosage of 200 mg three times daily for 1, 2, 3, 4, or 4 days.

Significant anthelmintic activity was observed in both trichuriasis and ascariasis but not in hookworm infection. Eighteen of 35 patients had side reactions in the form of nausea or vomiting, or both. In 4 patients the vomiting was so severe and persistent that the treatment had to be discontinued.

Because of its lack of activity against hookworm infection and the large number of patients with side reactions, it is felt that dithiazanine will be unsuitable for mass treatment in this country.