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Comparative Sensitivity of Viruses to Treatment with Diethyl Ether and Sodium Desoxycholate^*

H. Sunaga, R. M. Taylor AND J. R. Henderson

A comparison of the sensitivity of a selected number of viruses to treatment with diethyl ether (DE) and sodium desoxycholate (SDC) gave virtually identical results with each chemical.

Both DE and SDC inactivated all ten of the arthropod-borne viruses (representing serogroups A, B and C, and two ungrouped viruses) and two myxoviruses (influenza A and B). In contrast, poliovirus, two Coxsackie viruses, three ECHO viruses, and three adenoviruses were not inactivated by either DE or SDC treatment.

The application of these chemicals for categorizing viruses is briefly discussed.

^* This study was conducted under the auspices of the Commission on Viral Infections of the Armed Forces Epidemiological Board, and was supported in part by the Office of the Surgeon General, Department of the Army, and in part by a grant (E 1512) from the U. S. Public Health Service.

Rockefeller Foundation Fellow, 1958–59. Present address: Department of Preventive Medicine, Nagoya University School of Medicine, Nagoya, Japan.