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Am. J. Trop. Med. Hyg., 81(4), 2009, pp. 712-713
doi:10.4269/ajtmh.2009.09-0234;
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Intra-Cystic Drug Concentration of Albendazole Sulphoxide in Patients with Echinococcus granulosus Cysts

Mesküre Capan, Sebastian Keltner, Florian Thalhammer, Stefan Winkler, Walter Jäger, Markus Zeitlinger, AND Michael Ramharter*
Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Department of Clinical Pharmacy and Diagnostics, Faculty of Life Sciences, University of Vienna, Vienna, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Karl Landsteiner Gesellschaft, Infektiologie, St. Pölten, Austria

 

ABSTRACT

Albendazole therapy—alone or in combination with surgery—remains the standard of care for human echinococcosis depending on the stage of disease. However, only limited data are available on target site concentrations in liver cysts and data for non-liver cysts are lacking. We report on intra-cystic concentrations of the biologically active metabolite albendazole sulphoxide in non-liver cysts indicating a relative intra-cystic drug concentration of 48–156% compared with plasma levels. These data are evidence for a satisfactory penetration of albendazole sulphoxide into Echinococcus cysts localized in other organs than the liver and underline the usefulness of albendazole therapy for this indication.

Received May 4, 2009. Accepted for publication July 2, 2009.

Financial support: This work was supported by a grant of the independent Karl Landsteiner Gesellschaft, Austria.

* Address correspondence to Michael Ramharter, Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria. E-mail: michael.ramharter{at}meduniwien.ac.at

Authors’ addresses: Mesküre Capan, Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; and Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany. Sebastian Keltner, Florian Thalhammer, and Stefan Winkler, Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Walter Jäger, Department of Clinical Pharmacy and Diagnostics, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria. Markus Zeitlinger, Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Michael Ramharter, Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany; and Karl Landsteiner Gesellschaft, Infektiologie, Julius Raab Promenade 7 3100 St. Pölten, Austria.






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Copyright © 2009 by the American Society of Tropical Medicine and Hygiene.