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Am. J. Trop. Med. Hyg., 81(3), 2009, pp. 484-488
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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Risk Factors Leading to Fatal Outcome in Scrub Typhus Patients

Chang-Seop Lee, Jeong-Hwan Hwang, Heung-Bum Lee, AND Keun-Sang Kwon*
Departments of Internal Medicine, Preventive Medicine, Chonbuk National University Medical School, and Research Institute of Clinical Medicine, Jeonju, Republic of Korea

Scrub typhus is a potentially fatal infectious disease. However, to this date, no epidemiologic study on mortality of complicated scrub typhus has been reported. We reviewed the clinical records of 302 patients with diagnosis of scrub typhus who were admitted to our institute between January 2000 and December 2006. In total, 297 patients with scrub typhus were analyzed and the mortality rate of this study group was 6.1%. Multivariate logistic regression analysis revealed absence of eschar, event of intensive care unit admission and higher APACHE II score were independent predictive variables. Identification of these risk factors leading to fatal outcome may help physicians to start early intensive management of complicated scrub typhus.

Received August 6, 2008. Accepted for publication June 2, 2009.

* Address correspondence to Keun-Sang Kwon, Department of Preventive Medicine, Chonbuk National University Medical School, 634-18, Keumam-dong, Dukjin-gu, Jeonju, 561-712, South Korea. E-mail: drkeunsang{at}chonbuk.ac.kr

Authors’ addresses: Chang-Seop Lee, Jeong-Hwan Hwang, and Heung-Bum Lee, Department of Internal Medicine, Chonbuk National University Medical School, and Research Insitute of Clinical Medicine, Jeonju, Republic of Korea, E-mails: lcsmd{at}chonbuk.ac.kr, smilehwang77{at}hanmail.net, and lhbmd{at}chonbuk.ac.kr. Keun-Sang Kwon, Department of Preventive Medicine, Chonbuk National University Medical School, 634-18, Keumam-dong, Dukjin-gu, Jeonju, 561-712, South Korea, Tel: +82-63-270-3137, Fax: +82-63-274-9881, E-mail: drkeunsang{at}chonbuk.ac.kr.






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Copyright © 2009 by the American Society of Tropical Medicine and Hygiene.