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Am. J. Trop. Med. Hyg., 81(3), 2009, pp. 446-448
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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CASE REPORT


Bone Hydatid Disease Refractory to Nitazoxanide Treatment

Hans G. Schipper*, Suat Simsek, Michiel A. van Agtmael, AND Krijn P. van Lienden
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Amsterdam, The Netherlands; Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands; Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

 

ABSTRACT

We report a patient with bone hydatid disease that was refractory to both long-term daily treatment with albendazole, combined with cimetidine or administered as monotherapy (~15 years) and a relatively short course of nitazoxanide combined with albendazole (3 months). Despite continuous daily medical treatment, bone invasion and destruction proceeded. His pain and disability progressively increased.

Received April 7, 2009. Accepted for publication June 2, 2009.

* Address correspondence to Hans G. Schipper, Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. E-mail: H.G.Schipper{at}amc.uva.nl

Authors’ addresses: Hans G. Schipper, Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands, E-mail: H.G.Schipper{at}amc.uva.nl. Suat Simsek and Michiel A. van Agtmael, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. Krijn P. van Lienden, Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.






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