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Am. J. Trop. Med. Hyg., 80(6), 2009, pp. 953-955
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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Clinical Efficacy of Saccharomyces boulardii and Metronidazole Compared to Metronidazole Alone in Children with Acute Bloody Diarrhea Caused by Amebiasis: A Prospective, Randomized, Open Label Study

Ener C. Dinleyici*, Makbule Eren, Zeynel A. Yargic, Nihal Dogan, AND Yvan Vandenplas
Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Gastroenterology and Hepatology, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Parasitology, Eskisehir, Turkey; Universitair Ziekenhuis Brussel Kinderen, Vrije Universiteit Brussel, Brussels, Belgium

The aim was to evaluate the efficacy of Saccharomyces boulardii (Sb) in addition to metronidazole in amebiasis. A prospective, randomized, open clinical trial was performed in 50 children presenting with acute bloody diarrhea caused by Entameba histolytica. Group A and B (each N = 25) was treated with metronidazole, but Sb (250 mg, twice daily) during the 7 days was added to Group B patients who were re-evaluated 2, 3, 5, 10, and 30 days after diagnosis. Duration of bloody diarrhea was significantly longer in Group A (72.0 ± 28.5 versus 42.2 ± 17.4 hours, P < 0.001). On day 5, amebic cysts had disappeared in all children in Group B, whereas in Group A, amebic cysts were still present in 6 children (P < 0.05). On day 10, all children were cured and cysts had disappeared in all. The addition of Sb to metronidazole in amebiasis significantly decreases duration of (bloody) diarrhea and enhances clearance of cysts.

Received December 16, 2008. Accepted for publication March 7, 2009.

* Address correspondence to Ener C. Dinleyici, Department of Pediatrics, Eskisehir Osmangazi University, Faculty of Medicine, TR-26480 Eskisehir, Turkey. E-mail: timboothtr{at}yahoo.com

Authors’ addresses: Ener C. Dinleyici and Zeynel A. Yargic, Department of Pediatrics, Eskisehir Osmangazi University, Faculty of Medicine, TR-26480 Eskisehir, Turkey, Tel/Fax: +90-222-2290064, E-mails: timboothtr{at}yahoo.com and z_a_judge{at}yahoo.com. Makbule Eren, Department of Pediatrics, Division of Pediatric Gastro-enterology and Hepatology, Eskisehir Osmangazi University, Faculty of Medicine, TR-26480 Eskisehir, Turkey, Tel/Fax: +90-222-2290064, E-mail: makbule99{at}yahoo.com. Nihal Dogan, Eskisehir Osmangazi University Faculty of Medicine, Department of Parasitology, Eskisehir, Turkey, Tel: +90-222-23939279-4557, E-mail: ndogan{at}ogu.edu.tr. Yvan Vandenplas, Universitair Ziekenhuis Brussel Kinderen, Vrije Universiteit Brussel, Brussels, Belgium, Tel: 02-477-57-81, Fax: 02 477 57 83, E-mail: yvan.vandenplas{at}uzbrussel.be.






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Copyright © 2009 by the American Society of Tropical Medicine and Hygiene.