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Am. J. Trop. Med. Hyg., 80(6), 2009, pp. 941-943
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Protein Kinase A Regulatory Subunit Interacts with P-Type ATPases in Trypanosoma cruzi

Yi Bao, Louis M. Weiss, Muneaki Hashimoto, Takeshi Nara, AND Huan Huang*
Department of Pathology and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York; Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, Japan

 

ABSTRACT

Cyclic AMP–protein kinase A (PKA) signaling is important for the growth and differentiation of Trypanosoma cruzi. Immunofluorescence suggests that PKA can associate with the plasma membrane of trypomastigotes. We found that the PKA regulatory subunit interacts with several P-type ATPases. These P-type ATPases may play a role in anchoring PKA to the plasma membrane in T. cruzi.

Received September 26, 2008. Accepted for publication February 23, 2009.

Financial support: This work was supported by National Institutes of Health Grants AI 058893, AI076248, and AI05739.

* Address correspondence to Huan Huang, Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. E-mail: huangh{at}aecom.yu.edu

Note: A supplemental figure (Immunofluorescence analysis of T. cruzi using anti-TcPKAr [MAb] and TcPKAr is in membrane-associated fraction in trypomastigote) appears online at www.ajtmh.org.

Authors’ addresses: Yi Bao, Louis M. Weiss, and Huan Huang, Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. Muneaki Hashimoto and Takeshi Nara, Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.






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