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Am. J. Trop. Med. Hyg., 80(6), 2009, pp. 939-940
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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CASE REPORT


Drug Hypersensitivity Syndrome Induced by Meglumine Antimoniate

Fakhri Jeddi*, Eric Caumes, Marc Thellier, Stéphane Jauréguiberry, Dominique Mazier, AND Pierre A. Buffet
Service de Parasitologie-Mycologie, et Service de Maladies Infectieuses et Tropicales, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France; Unité de Mycologie Moléculaire, Institut Pasteur, Paris, France

 

ABSTRACT

We report a case of drug hypersensitivity syndrome (drug reaction with eosinophilia and systemic symptoms [DRESS]) induced by parenteral meglumine antimoniate (Glucantime) in a 40-year-old man who traveled to Bolivia and was treated for mucocutaneous leishmaniasis. Two weeks after starting therapy, the patient had fever, joint pain, a cutaneous eruption, and hypereosinophilia (1,358 cells/mm3). These symptoms resolved after drug withdrawal but reappeared upon reintroduction of the drug. Pentavalent antimonials should be definitively withdrawn in patients with hypereosinophilia > 1,000 cells/mm3 accompanied by systemic manifestations consistent with DRESS.

Received November 18, 2008. Accepted for publication February 11, 2009.

Acknowledgments: We thank Drs. Claude Campagne, Florence Gourdon, Olivier Lesens, and Dominique Lunte for contributing to patient care.

* Address correspondence to Fakhri Jeddi, Service de Parasitologie-Mycologie, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. E-mail: fakhri.jeddi{at}gmail.com

Authors’ addresses: Fakhri Jeddi, Marc Thellier, Dominique Mazier, and Pierre A. Buffet, Service de Parasitologie-Mycologie, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, E-mails: fakhri.jeddi{at}gmail.com, marc.thellier{at}psl.aphp.fr, dominique.mazier{at}psl.ap-hop-paris.fr, and pierre.buffet{at}psl.aphp.fr. Eric Caumes and Stéphane Jauréguiberry, Service de Maladies Infectieuses et Tropicales, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, E-mails: eric.caumes{at}psl.aphp.fr and stephane.jaureguiberry{at}psl.aphp.fr.






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