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Am. J. Trop. Med. Hyg., 80(6), 2009, pp. 927-928
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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CASE REPORT


Monkey Malaria in Humans: A Diagnostic Dilemma with Conflicting Laboratory Data

Catherine W. M. Ong*, Shir Ying Lee, Wee Hong Koh, Eng-Eong Ooi, AND Paul A. Tambyah
National University Health System, Singapore; Defence Medical and Environmental Research Institute, Singapore

 

ABSTRACT

Plasmodium knowlesi has recently been recognized as the fifth Plasmodium species causing malaria in humans. Diagnosis is difficult morphologically, and currently, available rapid tests have not been comprehensively evaluated with this pathogen. We report a case of P. knowlesi malaria that was confirmed after the initial clue of discordant microscopy and immunochromatographic results, highlighting the importance of molecular diagnostics in cases with the relevant clinical and epidemiologic history.

Received January 3, 2009. Accepted for publication February 24, 2009.

Acknowledgments: The authors thank Seok Wei Chew for helping with the definitive testing by molecular methods for this case. KWH and OEE conducted the molecular analysis of the specimen. LSY made the figures. CWMO, PAT, and OEE all contributed in writing the paper.

Disclosure: PAT has received research support from Baxter, Pfizer, Merck, Wyeth, and Interimmune.

* Address correspondence to Catherine W. M. Ong, Division of Infectious Disease, Department of Medicine, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074. E-mail: catongwm{at}yahoo.com

Authors’ addresses: Catherine W. M. Ong and Paul A. Tambyah, Division of Infectious Disease, Department of Medicine, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Tel: 65-6772-4362/4380, Fax: 65-6779-4361. Shir Ying Lee, Department of Haematology, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Tel: 65-6772-4362, Fax: 65-6779-4361. Wee Hong Koh and Eng-Eong Ooi, Defence Medical and Environmental Research Institute, 27 Medical Drive, Singapore 11750, Tel: 65-6776-2255, Fax: 65-6775-9011.






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