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Am. J. Trop. Med. Hyg., 80(5), 2009, pp. 739-744
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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Plasmodium fieldi: Observations on the Hackeri and ABI Strains in Macaca mulatta Monkeys and Mosquitoes

William E. Collins*, Joann S. Sullivan, McWilson Warren, G. Gale Galland, Allison Williams, AND John W. Barnwell
Division of Parasitic Diseases and Scientific Resources Branch, National Center for Vector-Borne and Infectious Diseases and National Center and National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Georgia

Macaca mulatta monkeys infected with the Hackeri strain of Plasmodium fieldi had maximum parasite counts ranging from 1,300 to 301,320/µL. In 43 intact animals infected with the ABI strain, the maximum parasite counts ranged from 672 to 57,189/µL (median = 15,100/µL); in 46 splenectomized monkeys, the maximum parasite count ranged from 660 to 350,000/µL (median = 52,245/µL). Transmission through Anopheles dirus mosquitoes was obtained on 11 occasions with pre-patent periods of 9–14 days. Relapses occurred between two and eight times during a 1-year period. P. fieldi has potential for testing prophylactic and radical curative drugs.

Received January 12, 2009. Accepted for publication January 16, 2009.

Acknowledgments: The authors thank the staff of the Animal Resources Branch, National Center for Preparedness, Detection and Control of Infectious Diseases for the care of the animals.

Financial support: This study was supported in part by an Interagency Agreement 936-3100-AA6-P-00-0006-07 between the US Agency for International Development and the Centers for Disease Control and Prevention. Aliquots of the Hackeri and the ABI strains of P. fieldi have been deposited with the American Type Culture Collection.

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

* Address correspondence to William E. Collins, Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne, and Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop F-36, 4770 Buford Highway Chamblee, GA 30341. E-mail: wec1{at}cdc.gov

Authors’ addresses: William E. Collins, Joann S. Sullivan, and John W. Barnwell, Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne, and Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop F-36, 4770 Buford Highway, Chamblee, GA 30341. McWilson Warren, Millbrook Road Box 417, Grafton, NH 03240. G. Gale Galland, Geographic Medicine and Health Promotion Branch, and Allison Williams, Animal Resources Branch, National Centers for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333.






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