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Analysis of Genetic Variability of Plasmodium vivax Isolates from Different Brazilian Amazon Areas Using Tandem Repeats

Few genetic markers have been described to analyze populations of Plasmodium vivax. The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These studies of genetic variability have neglected many areas with different epidemiologic profiles. The purpose of this study was to analyze the genetic variability of P. vivax isolates from four different Brazilian Amazon areas. We chose to study the five most polymorphic tandem repeats (TRs) identified so far. All TRs studied were polymorphic in at least one studied population, with a modal allele at nearly all loci. Expected heterozygosity ranged from 0.462 to 0.666 and did not correlate with the repeat array length. The genetic distances among the populations varied from 0.027 to 0.241, and did not correlate with their geographic separation. Tandem repeats identified in P. vivax isolates failed to allow geographic clustering.

Received July 22, 2008. Accepted for publication December 2, 2008.

Financial support: This work was supported by the Fundação de Amparo à Pesquisa de Minas Gerais (Fapemig), the Conselho Nacional de Pesquisa (CNPq), and PAPES/FIOCRUZ.

^* Address correspondence to Cristiana F. A. Brito, Laboratory of Malaria, Centro de Pesquisa Rene Rachou/Fiocruz, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte, MG, Brazil, 30190 002. E-mail: cristiana{at}cpqrr.fiocruz.br

Authors’ addresses: Antônio M. Rezende, Luzia H. Carvalho, and Cristiana F. A. Brito, Laboratory of Malaria, Centro de Pesquisa Rene Rachou/Fiocruz, Barro Preto, Belo Horizonte, MG, Brazil, 30190 002, Tel: +55-31-33497772, Fax: +55-31-32953115. Eduardo Tarazona-Santos, Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Álvaro D’Almeida Couto, Faculdade SEAMA, Macapá, Brazil. Cór Jésus F. Fontes, Departamento de Clínica Médica, Universidade Federal do Mato Grosso, Cuiabá, Brazil. José Maria de Souza, Instituto Evandro Chagas, Belém, Brazil.

Reprint requests: Cristiana F. A. Brito, Laboratory of Malaria, Centro de Pesquisa Rene Rachou/Fiocruz, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte, MG, Brazil, 30190 002, Tel: +55-31-33497772, Fax: +55-31-32953115, E-mail: cristiana{at}cpqrr.fiocruz.br.

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