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Am. J. Trop. Med. Hyg., 80(4), 2009, pp. 675-677
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Impact of HAART Therapy on Co-Infection of Tuberculosis and HIV Cases for 9 Years in Taiwan

Shu-Hui Tseng, Donald Dah-Shyong Jiang, Hao-Seong Hoi, Shiang-Lin Yang, AND Kao-Pin Hwang*
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan; Centers for Disease Control, Department of Health, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan

 

ABSTRACT

Free highly active antiretroviral therapy (HAART) was made available by The Department of Health since April 1997. As a result, the incidence rate of tuberculosis (TB)/human immunodeficiency virus (HIV) co-infection among HIV cases rose from 1.90% to 3.82% during 1993 to 1998 and decreased from 3.82% to 0.94% during 1998 to 2006. The incidence rate of TB/HIV co-infection among HIV cases reached its peak in 1998 and then started to reverse, although the next year the TB disease burden (incidence rate: 62.7 cases per 100,000 persons) remained consistently high, and this continued in the following years. The survival rate of TB/HIV co-infection cases was 62.16% during the period 1993–1996 (pre-free HAART era) and increased to 86.60% during the period 1998–2006 (P < 0.0001) (post-free HAART era). Highly active antiretroviral therapy decreased the incidence rate of new TB/HIV co-infection cases among HIV cases and increased the survival rate of TB/HIV co-infection cases.

Received October 22, 2008. Accepted for publication December 14, 2008.

Acknowledgments: We thank all the medical and public health staff in both local and federal authority to report HIV and tuberculosis cases to Taiwan CDC surveillance system and close follow-up those HIV and TB cases in Taiwan. We also thank director general Dr. Kuo of Taiwan CDC to supervise this research.

Financial support: This study was supported by the Centers for Disease Control, Taiwan (Taiwan CDC).

Disclosure: Shu-Hui Tseng is the deputy director of the division of surveillance and nosocomial infection control in Taiwan CDC. Her research interests focus on co-infection of HIV and tuberculosis.

* Address correspondence to Kao-Pin Hwang, Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, No. 123, Ta-Pei Rd., Niao-Sung Hsiang, Kaohsiung County, Taiwan, 83301. E-mail: kapihw{at}adm.cgmh.org.tw

Authors’ addresses: Shu-Hui Tseng, Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, No. 123, Ta-Pei Rd., Niao-Sung Hsiang, Kaohsiung County, Taiwan, 83301; Centers for Disease Control, Department of Health, Taiwan, No. 6 LinShen S. Rd., Taipei, Taiwan, 10050. Donald Dah-Shyong Jiang, Hao-Seong Hoi, and Shiang-Lin Yang, Centers for Disease Control, Department of Health, Taiwan, No. 6 LinShen S. Rd., Taipei, Taiwan, 10050. Kao-Pin Hwang, Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, No. 123, Ta-Pei Rd., Niao-Sung Hsiang, Kaohsiung County, Taiwan, 83301, Tel: 886-7-7317123 # 8713, Fax: 886-7-7321481, E-mail: kapihw{at}adm.cgmh.org.tw.






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Copyright © 2009 by the American Society of Tropical Medicine and Hygiene.