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Am. J. Trop. Med. Hyg., 80(4), 2009, pp. 555-558
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Resistance-mediating Polymorphisms in Plasmodium falciparum Infections in Kinshasa, Democratic Republic of the Congo

Linda Mobula, Bruce Lilley, Antoinette K. Tshefu, AND Philip J. Rosenthal*
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California; Ecole de Santé Publique, Faculté de Medecine, Université de Kinshasa, Republique Démocratique du Congo

 

ABSTRACT

Genetic polymorphisms in Plasmodium falciparum are associated with resistance to a number of drugs, but data on their prevalence are limited from many areas. We explored the prevalence of key polymorphisms in patients presenting with malaria in Kinshasa. Prevalences of pfcrt K76T; pfmdr1 N86Y; pfdhfr N51I, C59R, and S108N; and pfdhps A437G were well above 50% and of pfmdr1 Y184F, N1042D, and D1246Y; pfdhfr I164L; and pfdhps K540E were low. These results suggest an intermediate level of resistance to aminoquinoline and antifolate antimalarials in Kinshasa compared with other areas of Africa.

Received October 31, 2008. Accepted for publication December 21, 2008.

Acknowledgments: The authors thank Pius Mafuta, Dr. Edouard Mayimbi, Dr. Jack Kokolomami, Dr. Michel Kaya, Bicko Makubikwa Mamengi, Grec Kiloto Kakoma, and laboratory technicians at Clinic Riviera and at Kalembelembe. We also thank the children and their parents or guardians who participated in this study.

Financial support: This work was supported by the Doris Duke Charitable Foundation, of which PJR is a Distinguished Clinical Scientist.

* Address correspondence to Philip J. Rosenthal, Department of Medicine, Box 0811, University of California, San Francisco, CA 94143. E-mail: prosenthal{at}medsfgh.ucsf.edu

Authors’ addresses: Linda Mobula, Bruce Lilley, and Philip J. Rosenthal, Department of Medicine, Box 0811, University of California, San Francisco, CA 94143. Antoinette K. Tshefu, Ecole de Santé Publique, Faculté de Medecine, Université de Kinshasa, B.P. 11850 KIN I, Kinshasa, République Democratique du Congo.

Reprint requests: Philip J. Rosenthal, Department of Medicine, Box 0811, University of California, San Francisco, CA 94143.






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Copyright © 2009 by the American Society of Tropical Medicine and Hygiene.