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The Santa Lucia Strain of Plasmodium falciparum in Aotus Monkeys

The Santa Lucia strain of Plasmodium falciparum was studied in 150 Aotus lemurinus griseimembra, 30 A. azarae boliviensis, 103 A. nancymaae, and 121 A. vociferans monkeys. All four of these splenectomized hosts supported the production of gametocytes infective to Anopheles freeborni mosquitoes. Transmission through sporozoites from An. freeborni, An. stephensi, An. maculatus, and An. albimanus mosquitoes was successful to all four species of Aotus on a total of 100 occasions with a median pre-patent period of 21 days. For the production of infective mosquitoes for vaccine challenge studies, A. l. griseimembra and A. vociferans were the most predictable hosts.

Received September 10, 2008. Accepted for publication November 19, 2008.

Acknowledgments: The authors thank the staff of the Animal Resources Branch, the National Center for Infectious Diseases, for the care of the animals.

Financial support: This study was supported in part by an Interagency Agreement 936-3100-AA6-P-00-0006-07 between the US Agency for International Development and the Centers for Disease Control and Prevention.

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

^* Address correspondence to William E. Collins, Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne, and Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop F-36, 4770 Buford Highway, Chamblee, GA 30341. E-mail: wec1{at}cdc.gov

Authors’ addresses: William E. Collins, JoAnn S. Sullivan, Douglas Nace, and John H. Barnwell, Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne, and Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop F-36, 4770 Buford Highway, Chamblee, GA 30341. Allison Williams, Animal Resources Branch, and G. Gale Galland, Geographic Medicine and Health Promotion Branch, National Centers for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333. Tyrone Williams, Atlanta Research and Education Foundation, VA Medical Center, Atlanta, GA 30033.

This article has been cited by other articles:

				W. E. Collins, G. M. Jeffery, J. S. Sullivan, D. Nace, T. Williams, G. G. Galland, A. Williams, and J. W. Barnwell Infection of Mosquitoes with Plasmodium falciparum by Feeding on Humans and on Aotus Monkeys Am J Trop Med Hyg, September 1, 2009; 81(3): 529 - 533. [Abstract] [Full Text] [PDF]