AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 80(2), 2009, pp. 215-217
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Chloroquine-resistant Plasmodium vivax in the Republic of Korea

Kkot Sil Lee{dagger}, Tae Hyong Kim{dagger}, Eu Suk Kim, Hyeong-Seok Lim, Joon-Sup Yeom, Gyo Jun, AND Jae-Won Park*
Department of Internal Medicine, Kwandong University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Dongguk University College of Medicine, Seoul, Republic of Korea; Department of Pharmacology, Ulsan University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Departments of Microbiology and Biochemistry, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, Republic of Korea

 

ABSTRACT

The number of Plasmodium vivax malaria patients in the Republic of Korea and North Korea since the re-emergence of malaria in 1993 is estimated to be approximately one million. To cope with this situation, the Army of the Republic of Korea has performed chemoprophylaxis with hydroxychloroquine and primaquine since 1997. The cumulative number of soldiers in the Army of the Republic of Korea given chemoprophylaxis exceeded 1.4 million by 2007. Extensive chemoprophylaxis contributed to preventing a rapid increase of malaria patients in the Army of the Republic of Korea, but increased the possibility of the occurrence of chloroquine (CQ)–resistant P. vivax strains. In this study, treatment responses of P. vivax malaria patients in the Republic of Korea monitored during 2003–2007, and CQ resistance was confirmed in 2 of 484 enrolled patients. Our results are the first report of CQ-resistant P. vivax in a temperate region of Asia. Continuous surveillance is warranted to monitor the change in CQ resistance frequency of P. vivax in the Republic of Korea.

Received August 14, 2008. Accepted for publication November 1, 2008.

Acknowledgments: We thank Young-A Kim, Sun-Young Ahn, Mi-Young Shin, and Ji-Ae Yoo for technical support.

Financial support: This study was supported by a grant from the Korea Health 21 Research and Development project, the Ministry of Health and Welfare, the Republic of Korea (A030075), and a grant from the Korea Centers for Disease Control and Prevention, the Republic of Korea (no. 2008-E00139-00).

* Address correspondence to Jae-Won Park, Department of Microbiology, Graduate School of Medicine, Gachon University of Medicine and Science 1198, Kuwol-1-dong, Namdong-gu, Incheon 405-760, Republic of Korea. E-mail: seorak{at}dreamwiz.com

{dagger} These authors contributed equally to this work.

Authors’ addresses: Kkot Sil Lee, Department of Internal Medicine, Kwandong University College of Medicine, 697-24, Hwajeong-dong, Deokyang-gu, Goyang-si, Kyonggi-do 412-270, Republic of Korea. Tae Hyong Kim, Department of Internal Medicine, Soonchunhyang University College of Medicine, 657, Hannam-dong, Yongsan-gu, Seoul 140-743, Republic of Korea. Eu Suk Kim, Department of Internal Medicine, Dongguk University College of Medicine, 814, Siksa-dong, Ilsandong-gu, Goyang-si, Kyonggi-do 411-773, Republic of Korea. Hyeong-Seok Lim, Department of Pharmacology, Ulsan University College of Medicine, 388-1, Pungnap-2-dong, Songpa-gu, Seoul 138-736, Republic of Korea. Joon-Sup Yeom, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108, Pyung-dong, Chongno-gu, Seoul 110-746, Republic of Korea. Gyo Jun, Department of Biochemistry, Graduate School of Medicine, Gachon University of Medicine and Science, 1198, Kuwol-1-dong, Namdong-gu, Incheon 405-760, Republic of Korea. Jae-Won Park, Department of Microbiology, Graduate School of Medicine, Gachon University of Medicine and Science, 1198, Kuwol-1-dong, Namdong-gu, Incheon 405-760, Republic of Korea.




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G. Jun, J.-S. Yeom, J.-Y. Hong, E-H. Shin, K.-S. Chang, J.-R. Yu, S. Oh, H. Chung, and J.-W. Park
Resurgence of Plasmodium vivax Malaria in the Republic of Korea during 2006-2007
Am J Trop Med Hyg, October 1, 2009; 81(4): 605 - 610.
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