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Am. J. Trop. Med. Hyg., 80(2), 2009, pp. 176-178
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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CASE REPORT


Nitazoxanide for Treatment of Refractory Bony Hydatid Disease

Alison Winning*, Phillip Braslins, AND James S. McCarthy
Department of Infectious Diseases, Royal Brisbane and Women’s Hospital, Brisbane, Queensl and Australia; Queensland Institute of Medical Research and Australian Centre for International and Tropical Health and Nutrition, Herston, Queensland, Australia; Department of Medicine, Central Clinical Division, University of Queensland, Brisbane, Queensland, Australia

 

ABSTRACT

Although nitazoxanide has been shown to have activity against Echinococcus multilocularis in animal studies and against E. granulosus in vitro, its use in treatment of human cystic echinococcosis has not been reported. We report a case of progressive bony hydatid disease treated with nitazoxanide that showed a clinical and radiologic response. The patient had a 40-year history of hydatid disease involving the left hip. Despite prolonged courses of albendazole and praziquantel, she had progressive disease with extensive involvement of the left hemipelvis and adjacent soft tissue cysts. She was treated with nitazoxanide, 500 mg twice a day for 3 months in combination with albendazole. The clinical response was supported by imaging showing marked improvement in the soft tissue cysts, with stable disease in the bony pelvis. Although further studies are required, this case suggests that nitazoxanide may be an effective treatment option in hydatid disease, particularly in patients with progressive disease who are receiving conventional therapy.

Received June 11, 2008. Accepted for publication August 13, 2008.

* Address correspondence to Alison Winning, Department of Infectious Diseases, Royal Brisbane and Women’s Hospital, Brisbane, Queensland 4006, Australia. E-mail: alison_winning{at}health.qld.gov.au

Authors’ addresses: Alison Winning and Phillip Braslins, Department of Infectious Diseases, Royal Brisbane and Women’s Hospital, Brisbane, Queensland 4006 Australia. James S. McCarthy, Department of Infectious Diseases, Royal Brisbane and Women’s Hospital, Brisbane, Queensland 4006, Australia and Queensland Institute of Medical Research and Australian Centre for International and Tropical Health and Nutrition, Herston, Queensland 4029, Australia.




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H. G. Schipper, S. Simsek, M. A. van Agtmael, and K. P. van Lienden
Bone Hydatid Disease Refractory to Nitazoxanide Treatment
Am J Trop Med Hyg, September 1, 2009; 81(3): 446 - 448.
[Abstract] [Full Text] [PDF]


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