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Am. J. Trop. Med. Hyg., 80(1), 2009, pp. 33-35
Copyright © 2009 by The American Society of Tropical Medicine and Hygiene

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Right arrow Gnathostomiasis

Long-term Follow-up of Imported Gnathostomiasis Shows Frequent Treatment Failure

Christophe Strady*, Paron Dekumyoy, Marina Clement-Rigolet, Martin Danis, François Bricaire, AND Eric Caumes
Department of infectious and tropical diseases, la Pitié Salpêtrière Hospital, France; Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Gnathostomiasis is increasingly reported among travelers returning from endemic areas. Between 2000 and 2004, thirteen patients were diagnosed with imported gnathostomiasis and followed for at least 6 months after treatment. Nine patients presented with cutaneous signs, two with gastrointestinal signs, and two with neurological signs. The median age was 38 years and the female/male sex ratio was 1.6. The patients had visited South East Asia or Central America. The median interval between symptom onset and treatment (with albendazole in 12 cases and ivermectin in one case) was 3.5 months. Post-treatment follow-up lasted a median of 15 months. Eight patients relapsed, a median of 2 months (1–7 months) after initial treatment. These eight patients had a total of 13 relapses, the last occurring a median of 16 months (2–26 months) after initial treatment. Thus patients with imported gnathostomiasis should be monitored for at least 6 months to detect late treatment failure.

Received March 5, 2008. Accepted for publication July 7, 2008.

* Address correspondence to Christophe Strady, Service de médicine interne et des maladies infectieuses, Hôpital Robert Debré–CHU Reims, Avenue du général Koenig, 51093 Reims Cedex, France. E-mail: cstrady{at}chu-reims.fr

Authors’ addresses: Christophe Strady, Department of infectious and tropical diseases, La Pitié Salpêtrière Hospital, 75013 Paris, France, Tel: 00333-26-78-78-94, Fax: 00333-26-78-40-90, E-mail: cstrady{at}chu-reims.fr. Paron Dekumyoy, Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand, E-mail: tmpdk{at}mahidol.ac.th. Marina Clement-Rigolet, Martin Danis, François Bricaire, and Eric Caumes, Department of Infectious and Tropical Diseases, La Pitié Salpêtrière Hospital, 75013 Paris, France, E-mails: marina.clement-rigolet{at}psl.aphp.fr, martin.danis{at}psl.aphp.fr, francois.bricaire{at}psl.aphp.fr, and eric.caumes{at}psl.aphp.fr.




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 Clin. Microbiol. Rev.Home page
J. S. Herman and P. L. Chiodini
Gnathostomiasis, Another Emerging Imported Disease
Clin. Microbiol. Rev., July 1, 2009; 22(3): 484 - 492.
[Abstract] [Full Text] [PDF]


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Copyright © 2009 by the American Society of Tropical Medicine and Hygiene.