HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Collins, W. E. Articles by Barnwell, J. W. Search for Related Content PubMed PubMed Citation Articles by Collins, W. E. Articles by Barnwell, J. W. Related Collections Malaria

The Chesson Strain of Plasmodium vivax in Humans and Different Species of Aotus Monkeys

Comparison was made between the parasitemia of Chesson strain Plasmodium vivax in humans and in splenectomized Aotus lemurinus griseimembra, A. nancymaae, A. vociferans, and A. azarae boliviensis monkeys. In the monkeys, 56.3% of the animals had maximum counts > 25,000/µL and in humans 59.6% were above this peak parasitemia. In humans, it took an average of 9.3 days to reach the maximum parasite count. In monkeys with no previous infections, it took an average of 18.9 days to reach the maximum parasite count; for those with previous infections, it took an average of 15 days. Human and nonhuman primate data on this parasite suggest that splenectomized Aotus monkeys, particularly A. lemurinus griseimembra, and to a somewhat lesser extent A. vociferans, can mimic the course of Chesson malaria in humans regarding parasitemia and mosquito infection.

Received September 17, 2008. Accepted for publication September 24, 2008.

Acknowledgments: The authors thank the staff of the Animal Resources Branch, the National Center for Infectious Diseases, for the care of the animals.

Financial support: This study was supported in part by an Interagency Agreement 936-3100-AA6-P-00-0006-07 between the US Agency for International Development and the Centers for Disease Control and Prevention.

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

^* Address correspondence to William E. Collins, Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Infectious Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Chamblee, GA 30341. E-mail: wec1{at}cdc.gov

Authors’ addresses: William E. Collins, JoAnn S. Sullivan, Douglas Nace, and John W. Barnwell, Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Infectious Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Chamblee, GA 30341. Geoffrey M. Jeffery, 1085 Blackshear Dr., Apt. B, Decatur, GA 30033. Allison Williams, Animal Resources Branch, and G. Gale Galland, Division of Global Migration and Quarantine, National Centers for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333. Tyrone Williams, Atlanta Research and Education Foundation, 1670 Clairmont Rd., Decatur, GA 30033.