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Am. J. Trop. Med. Hyg., 79(6), 2008, pp. 915-917
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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CASE REPORT


Severe, Symptomatic Hypomagnesemia in Acute Leptospirosis

Anne Spichler, Daniel A. Athanazio, Juvencio Furtado, Antonio Seguro, AND Joseph M. Vinetz*
Department of Nephrology, University of São Paulo School of Medicine, São Paulo, Brazil; Department of Infectious Diseases, Emilio Ribas Institute of Infectious Diseases, São Paulo, Brazil; Department of Biointeraction, Federal University of Bahia, Salvador, Bahia, Brazil; Department of Infectious Diseases, Heliopolis General Hospital, São Paulo, Brazil; Division of Infectious Diseases, University of California San Diego School of Medicine, La Jolla, California

 

ABSTRACT

We report a case of severe hypomagnesemia in non-oliguric acute renal failure caused by leptospirosis that required large doses of magnesium replacement during the acute phase of disease. Biochemical studies confirmed kidney-related magnesium wasting and the mechanisms of this defect are discussed. Magnesium imbalance with its attendant clinical complications occurs in leptospirosis and should be monitored and treated aggressively in cases of leptospirosis-induced non-oliguric acute kidney injury.

Received June 8, 2008. Accepted for publication August 20, 2008.

Acknowledgments: We thank the physicians and staff of the Heliopolis General Hospital (São Paulo, Brazil) for excellent care of the patient.

Financial support: This study was supported in part by U.S. Public Health Service grant 1K24AI068903 to Joseph M. Vinetz.

Disclosure: The authors have no conflicts of interest.

* Address correspondence to Joseph M. Vinetz, Division of Infectious Diseases, University of California San Diego School of Medicine, 9500 Gilman Drive, 0741, Palade Laboratories, Room 125, La Jolla, CA 92093-0741. E-mail: jvinetz{at}ucsd.edu

Authors’ addresses: Anne Spichler and Antonio Seguro, Department of Nephrology, LIM 12, University of São Paulo School of Medicine, São Paulo, Brazil and Department of Infectious Diseases, Emilio Ribas Institute of Infectious Diseases, São Paulo, Brazil. Daniel A. Athanazio, Department of Biointeraction, Federal University of Bahia, Salvador, Brazil. Juvencio Furtado, Department of Infectious Diseases, Heliopolis General Hospital, São Paulo, Brazil. Joseph M. Vinetz, Division of Infectious Diseases. University of California San Diego School of Medicine, La Jolla, CA 92093-0741.




This article has been cited by other articles:


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S. B. Craig, L. D. Smythe, G. C. Graham, and D. B. Mckay
Hypomagnesemia in Acute Leptospirosis
Am J Trop Med Hyg, June 1, 2009; 80(6): 1067 - 1067.
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