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Am. J. Trop. Med. Hyg., 79(6), 2008, pp. 843-846
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Positive rK39 Serologic Assay Results in US Servicemen with Cutaneous Leishmaniasis

Joshua D. Hartzell*, Naomi E. Aronson, Peter J. Weina, Robin S. Howard, Anjali Yadava, AND Glenn W. Wortmann
Infectious Diseases Division, Walter Reed Army Medical Center, Washington, District of Columbia; Division of Infectious Disease, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Walter Reed Army Institute of Research, Silver Spring, Maryland; Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, District of Columbia

The rK39 test is a serologic assay for the rapid diagnosis of visceral leishmaniasis (VL). Serum from a North American cohort of 59 otherwise asymptomatic soldiers with cutaneous leishmaniasis (CL) was tested with the rK39 dipstick and ELISA assays, and 10.2% and 28.8% had positive results, respectively. CL is associated with a reactive rK39 assay result in some patients without clinical evidence of VL.

Received May 8, 2008. Accepted for publication August 13, 2008.

Acknowledgments: The authors thank Oral Cephas, James Cummings, Kim Moran, Juan Mendez, and Mark Polhemus for assistance with this study.

Financial support: This study was supported by the Infectious Disease Clinical Research Program and Military Infectious Disease Research Program.

Disclaimer: The views expressed are those of the authors and should not be construed to represent the positions of Walter Reed Army Medical Center, the Department of the Army, or the Department of Defense.

* Address correspondence to Joshua D. Hartzell, US Army Infectious Disease Fellow, Walter Reed Army Medical Center BLD 2, Ward 63, 6900 Georgia Avenue NW, Washington, DC 20307. E-mail: joshua.hartzell{at}amedd.army.mil

Authors’ addresses: Joshua D. Hartzell, Walter Reed Army Medical Center BLD 2, Ward 63, 6900 Georgia Ave. NW, Washington, DC 20307, Tel: 202-782-1663, Fax: 202-782-3765. Naomi E. Aronson, Room A3060, USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814, Tel: 301-295-3621, Fax: 301-295-3557. Peter J. Weina, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD 20910, Tel: 301-319-9956, Fax: 301-319-7360. Robin S. Howard, Biometrics Service, Department of Clinical Investigation, Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Bldg. 6, Rm. 4045, Washington, DC 20307-5001, Tel: 202-782-7878. Anjali Yadava, US Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, Tel: 301-319-9577, Fax: 301-319-7358. Glenn W. Wortmann, Walter Reed Army Medical Center, Bldg. 2, Ward 63, 6900 Georgia Ave. NW, Washington, DC 20307, Tel: 202-782-1663, Fax: 202-782-3765.






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