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Am. J. Trop. Med. Hyg., 79(6), 2008, pp. 819-822
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Concurrent Infection with Heligmosomoides polygyrus Modulates Murine Host Response against Plasmodium berghei ANKA Infection

Kohhei Tetsutani*, Kenji Ishiwata, Motomi Torii, Shinjiro Hamano, Hajime Hisaeda, AND Kunisuke Himeno
Department of Parasitology, Kyushu University Graduate School of Medicine, Fukuoka, Japan; Department of Tropical Medicine, The Jikei University School of Medicine, Tokyo, Japan; Department of Molecular Parasitology, Ehime University School of Medicine, To-on, Ehime, Japan

 

ABSTRACT

We investigated whether concurrent infection with Heligmosomoides polygyrus, an intestinal nematode, modulated anti-malaria parasite immunity and development of experimental cerebral malaria (ECM) in mice. The C57BL/6 mice infected with Plasmodium berghei ANKA showed typical symptoms of ECM. Interestingly, preceding H. polygyrus infection did not alter ECM development, despite accelerated P. berghei growth in vivo. Our observation provides a new insight that ECM can be induced in a fashion independent of the immune responses affected by concurrent H. polygyrus. Differentiation between protective immunity and infection-associated host-damaging inflammatory response is urgently required for understanding the pathogenesis of cerebral malaria.

Received April 19, 2008. Accepted for publication August 20, 2008.

Financial support: This work was supported by the Ministry of Education, Science, Sport and Culture of Japan (Grants 20390121, 19041056), and by the Uehara Memorial Foundation.

* Address correspondence to Kohhei Tetsutani, Department of Parasitology, Kyushu University Graduate School of Medicine, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-0054, Japan. E-mail: tetztani{at}parasite.med.kyushu-u.ac.jp

Authors’ addresses: Kohhei Tetsutani, Shinjiro Hamano, Hajime Hi-saeda, and Kunisuke Himeno, Department of Parasitology, Kyushu University Graduate School of Medicine, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-0054, Japan, Tel: +81-92-642-6117, Fax: +81-92-642-6118, E-mail: tetztani{at}parasite.med.kyushu-u.ac.jp. Kenji Ishiwata, Department of Tropical Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, Japan. Motomi Torii, Department of Molecular Parasitology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.




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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.